Yep - I do precisely this so I can dedicate a tuner to each UK mux - so zero chances of live or recording channel clash.
I've created 9 networks :
PSB1
PSB2
PSB3
COM4
COM5
COM6
COM7
COM8
Local
I've associated each tuner with one network, and added a single mux to each network (So Network PSB1 is associated to DVB-T Tuner front-end 1, and has one mux associated with it at 490MHz - as I live in Crystal Palace's footprint) I've disabled any form of network discovery or any form of mux updates (I manually update when the line-up changes), so each network remains to only have one mux within it.
I've attached PSB3, COM7 and COM8 to DVB-T2 tuners (a single August T210v1 and a Hauppauge WinTV Dual HD), and PSB1, PSB2, COM4, COM5, COM6 and Local to 3 x Dual DVB-T tuners (Playstation Play TV). I had to roll my own kernel to get round the 8 tuner limit, and to include full dual driver support for the Hauppauge. I'm running them on a Celeron Chromebox with GigE and USB 3.0.
This has proved to work effectively - and whilst it might seem overkill. It just works.